Samat Isabekov was born in 1972. In 1995, he graduated from Kyrgyz National University with specialty in Law Studies; and in 2009, from the Diplomatic Academy of the Ministry of Foreign Affairs of Kyrgyzstan with specialty in International Relations.

Since 1996, he served in customs authorities of the Kyrgyz Republic, holding field and management positions.

In June 2021, he was appointed Chairman of the State Customs Service under the Ministry of Economy and Finance of the Kyrgyz Republic. He is Major General of the Customs Service.

Since December 10, 2025 he was appointed Director of the Eurasian Economic Commission's Customs Infrastructure Department.